Jobs

Postdoc Position in Proteomics and Biomarker Discovery (80%)

Laboratory of Clinical Chemistry, Zürich University of Applied Sciences

The Laboratory of Clinical Chemistry at the Zürich University of Applied Sciences is seeking a highly motivated Postdoctoral Researcher in the field of Mass Spectrometry, Proteomics, and Biomarker Discovery. This position is available immediately.

Your Role
This position offers a unique opportunity to conduct innovative research in proteomics and biomarker discovery, with a focus on integrating advanced mass spectrometry technologies with biochemical workflows to discover new biomarkers and potential drug targets. Your primary responsibilities:

• Leveraging experience with advanced LC-MS/MS systems (e.g., Q-TOF, Orbitrap, etc) and adapting methodologies to the research objectives.
• Designing workflows and conducting discovery and targeted proteomics experiments using techniques such as data-dependent acquisition (DDA), data-independent acquisition (DIA), label-free quantification (LFQ), or isotopic labeling to achieve comprehensive proteome coverage and precise quantitation of biomolecules.
• Analyzing complex proteomics datasets using state-of-the-art data analysis tools and interpreting results in a biological context
• Establishing and Implementing biochemical workflows, including protein purification, pull-down assays, and immunoprecipitation (IP), for studying protein interactions and functional characterization. 
• Development of chemoproteomics workflows by using activity-based probes for targeting and profiling active proteins and integrating this data with conventional proteomics approaches for biomarker discovery and functional studies.
• Handling diverse human biological samples, including plasma, serum, and tissues.
• Supporting the development of cellular models for functional studies.
• Working independently while actively collaborating with group members on shared projects, publish manuscripts in peer-reviewed journals, assist in application for third-party funding and present findings at lab meetings and international conferences.
• Supervise junior staff, and support teaching activities of students within the institute.

 

Your Profile

• A Ph.D. in Biochemistry, Chemical Biology, or a related field.
• A strong publication record demonstrating expertise in advanced mass spectrometry technologies and proteomics workflows.
• Hands-on experience with high-resolution LC-MS/MS systems (e.g., Q-TOF or Orbitrap) and their applications in complex biological systems and familiarity with sample preparation techniques for proteomics, including protein extraction, digestion, and fractionation.
• Expertise in proteomics data analysis using state of the art software.
• Competence in protein biochemistry, performing biochemical assays and workflows and working with human clinical samples (Serum, Plasma, tissues, etc)
• Additional experience in working with chemoproteomics workflows or expertise in combining limited proteolysis with mass spectrometry will be given a special consideration.
• Experience in cell biology or cell culturing techniques (2D and 3D) techniques is considered a plus.

 

Apply online on the company job site

Assistant engineer position in N-terminomics at I2BC University Paris-Saclay (20km south of Paris): 10 months

Working context: The Institute for Integrative Biology of the Cell (I2BC) is a large mixed research unit created on January 1, 2015. It is jointly supervised by the CNRS, CEA, and Université Paris-Saclay, with additional partnerships including INRAe, INSERM, and Université Paris Diderot, among others. Located 20 km from Paris, France, the institute fosters interdisciplinary research at the cutting edge of biological sciences (https://www.i2bc.paris-saclay.fr).

Host laboratory: Our research group (Protein Maturation, Cell fate and Therapeutics, https://www.i2bc.paris-saclay.fr/equipe-protein-maturation-cell-fate-therapeutics/), headed by C. Giglione, is seeking a highly motivated and skilled assistant engineer to join our team. Our group focuses on a range of modifications that affect proteins. These modifications share the common feature of targeting reactive amino groups, either at the N-terminus or on the side chains of lysines. The team aims to understand the nature and biological effects of these modifications as well as the impact of these modifications on the maintenance of a functional proteome. In this context, our research focus includes identifying the protein populations involved, exploring competition between different modifications on the same chemical group, and examining the physiological adjustment of their stoichiometry, which lies at the heart of proteostasis. Protein analysis and modification studies are conducted using mass spectrometry, leveraging instruments managed by the platform adjacent to the team’s location. The properties of the enzymes catalyzing these modifications are characterized both in vitro through biochemical approaches and in vivo through genetic methods (e.g., loss-of-function studies). The nature of the modifications can also be analyzed in cell extracts from various species using targeted approaches for specific amino groups or broader methods. In all cases, a quantitative analysis is prioritized and carefully examined. Computational tools and databases are developed to support these analyses. Additionally, biophysical in vitro studies or in-cellulo cellular biology approaches are employed to enhance the understanding of the distribution of modified proteins across different compartments.

Candidate’s profile: We are looking for an assistant engineer with experience in protein biochemistry (fractionation using high or medium-pressure chromatography) and mass spectrometry techniques. Experience in approaches for N-terminal proteomic characterization and quantification in complex extracts as well as protein modification enrichment and analysis will be highly appreciated. Over time, the candidate will be expected to independently conduct routine MS experiments and analyze the resulting data.

This opportunity is ideal for someone who is driven, curious, and passionate about proteomics and 
protein biochemistry.

Salary: ~40 k€ for 10 months (extension possible depending on funding)

How to Apply:
If this opportunity aligns with your skills and career aspirations, please send your CV with at least two references and a cover letter outlining your relevant experience and motivation to Carmela Giglione at CNRS (Email) and Carmela Giglione at I2BC (Email). 

PhD (m/f/d) position in the MSCA Doctoral Network “MobiliTraIN” on fundamental ion mobility research

Bremen

Overview

As one of the world’s leading analytical instrumentation companies, Bruker covers a broad spectrum of advanced solutions in all fields of research and development. All our systems and instruments are designed to improve safety of products, accelerate time-to-market and support industries in successfully enhancing quality of life. We’ve been driving innovation in analytical instrumentation for 60 years now. Today, worldwide more than 6,200 employees are working on this permanent challenge, at over 90 locations on all continents.

At Bruker R&D we are a team of leading physicists, chemists, and data scientists, who daily take on the challenge of developing mass spectrometry instrumentation that can unravel fundamental properties of molecular systems. We have a strong network of collaborators from industrial partners as well as academic institutions and are thus deeply involved in state-of-the-art academic research. We deeply value reproducible, transparent results and support open-source software developments.

MobiliTrAIN is a Marie Sklodowska-Curie Action Doctoral Network aiming to bring new fundamental understanding of ion mobility high resolution mass spectrometry (IM-HRMS), provide reference materials and guidelines for standardisation, develop state-of-the-art methods for the application of IM-HRMS in biopharmaceutical development, biological omics studies and non-target screening of contaminants, and lay the foundations for the adoption of IM-HRMS in industry by training 13 doctoral candidates.

The MobiliTraIN network brings together some of the most innovative minds in the ion mobility and mass spectrometry communities, thereby covering a large range of applications from biomedicine to environmental science. The network is formed by different academic and industrial partners from all around Europe and foresees a close interaction between all partners in the form of joint symposia and training workshops. This strong international scientific background, combined with the direct interaction between academia and industry and the possibility of performing research stages at different institutions, represent an ideal framework for the personal and scientific development of a young researcher. Visit the website for additional job details: https://www.mobilitrain.eu

More specifically, this position offers:

• A thorough scientific education in the frame of an EU doctoral training programme.
• A strong involvement in a research project with high international visibility.
• The possibility to participate in specific international training courses, workshops, and conferences.
• The possibility to perform research visits to internationally renowned research labs in Europe.
• A prestigious three-year MSCA Fellowship.
• Working in the international R&D environment of one of the most renowned mass spectrometry vendors.
• Acquiring direct experience in merging fundamental research with instrument development.
• A competitive PhD salary
• Yearly travel allowance to perform research internships as part of the doctoral network, as well as visiting international conferences and workshops.
• Yearly family allowance (if applicable)

 

Responsibilities

The PhD candidate will be employed by Bruker Daltonics GmbH & Co. KG (Bremen, Germany) and will be enrolled in the PhD program of the Jena University Hospital. The candidate will use state-of-the-art instrumentation to investigate fundamental characteristics of tandem ion mobility spectrometry (TIMS) devices. In an interdisciplinary research and prototyping team at Bruker, the candidate will work in collaboration with other university research labs, using the gained fundamental insights to develop novel biomedically relevant workflows and interpret the corresponding results.  

Some of the specific tasks are:

• Locate, quantify, and control the effect of the ion’s translational temperature on their internal temperatures and potential fragmentation in different TIMS configurations.
• Develop and demonstrate a 1st order CCS determination. From the TIMS theory, this technique will be comparable to the well-established 1st order CCS determination on the drift tube IMS instruments.
• Translate the deep understanding of TIMS technology to the biomedical investigations of the different research labs present on the doctoral network.
• Contributing to a general way of evaluating and compare fundamental physical properties and result outcomes using different ion mobility spectrometry techniques.

 

Qualifications

• Diploma or M.Sc. in Physics, Physical Chemistry or corresponding qualification.
• Knowledge and experience in one or more of the following areas:
• Ion mobility spectrometry
• Mass spectrometry
• Ion optics and physics
• Python programming
• Gas phase instrument development
• Strong analytic, logical, and innovative thinking.
• Good communication skills, team-mindedness.
• First experience in the preparation and writing of scientific publications.
• Solid scientific English language skills (oral and written).
• Fluid German language skills would be beneficial.

 

Apply for this PhD position via the company job site (#2024-15545). 

R&D Software Developer

Our scientists and engineers design, manufacture, and optimize high performance mass spectrometers for new applications to support researchers and industrial customers around the world.  We are headquartered in Thun, Switzerland, with regional offices in China, Japan, Korea and the United States. Our diverse team members cultivate a collaborative and creative work environment. Together we deliver the highest quality products and service to ensure our customers’ success.

Location: Thun, Switzerland

 

Description

TOFWERK is seeking a software engineer to strengthen our team developing software for our time-of-flight mass spectrometers. The successful applicant will combine programming and scientific experience with their communication skills to meet the tailored requirements for a diverse set of stakeholders and customers. They will work in tandem with R&D teams, other software team members, and members of the product teams to integrate the user interface applications with the underlying TOFWERK libraries and services driving the instrument control functionality. They will directly liaise with the R&D and instrument teams in rapid development of software during prototyping and feedback cycles, and to ensure that the stakeholders requirements are comprehensively documented. Based on their knowledge of the field and use of TOFWERK technology, they will provide suggestions and feedback regarding potential short- and long-term product improvements and developments.

 

Required Skills

• 3+ years experience in software development using C#
• Master’s level education in the sciences
• Relevant certification or proven track record in front-end software engineering
• Interest in collaborating with non-software R&D staff and product teams
• Independent, well-structured, and goal-oriented working style
• Fluency in English

 

Desired Skills 

• Experience using Agile development principles, particularly Kanban
• Experience working as part of an international team across multiple time zones
• Basic proficiency in German
• Knowledge of Python and/or C++

 

What We Offer 

• Exciting projects in state-of-the-art mass spectrometry
• Working with a creative international team
• An open culture that encourages new ideas
• Flexible working hours
• A bright, spacious workplace in beautiful Thun, Switzerland
• Attractive pension scheme

 

We look forward to receiving your application by email, Reference HR-693