Jobs

L’Université de Neuchâtel

Met au concours un poste de

Laborantin-e en biologie

à temps complet (100%)

à repourvoir au sein de l’Institut de biologie du Laboratoire d’Ecologie Chimique, rattaché à la Faculté des sciences de l’Université de Neuchâtel.

Activités :

En votre qualité de laborantin-e, vous participez aux activités de recherches en écologie chimique sous la direction des professeurs de l’Institut. Vous réalisez des analyses chimiques en Chromatographie en Phase Gazeuse (GC), comprenant la préparation des échantillons, la maintenance des instruments ainsi que le contrôle qualité des analyses effectuées. Vous apportez également un soutien aux projets de recherche en cours facilitant l’acquisition et l’analyse préliminaire des données.

En outre, vous supervisez les opérations quotidiennes du laboratoire, notamment la gestion des commandes de consommables, la gestion des stocks et la maintenance des instruments. Vous veillez à l’organisation, à la propreté du laboratoire et au respect des protocoles de sécurité, tout en coordonnant avec le personnel d’entretien du bâtiment et le régisseur de l’Institut de biologie.

Vous apportez un soutien à la formation et à l’enseignement en accompagnant les étudiant-e-s dans leurs activités de recherche, en les formant aux techniques de laboratoire et à l’utilisation des équipements. Vous participez également au recrutement et à l’encadrement des apprenti-e-s, en développant leurs compétences techniques. Enfin vous préparez les matériaux et les équipements nécessaires aux travaux pratiques pour les étudiant-e-s des niveaux Bachelor et Master. 

Exigences :

Au bénéfice d’un certificat fédéral de capacité en techniques de laboratoire ou d’un titre jugé équivalent, vous disposez d’une capacité à travailler de manière autonome et à organiser ses activités en fonction des priorités. Vous avez le sens des responsabilités et faites preuve de réactivité. 
Vous disposez d’une expérience confirmée dans les techniques requises par le poste telle que les compétences en GC-MS. Nous précisons qu’une expérience en extraction chimique serait un atout.
Vous faites preuve d’un esprit ouvert et d’une capacité à s’intégrer dans une équipe. Vous êtes motivé-e à apprendre de nouvelles techniques de laboratoire et avez un intérêt marqué pour l’innovation. Détenant des capacités d’analyses, vous maîtrisez les logiciels Office standard (Excel, Word) et avez d’excellentes connaissances du français et de de très bonnes connaissances en anglais. 

Entrée en fonction : 1er avril 2025 ou à convenir

Délai de postulation 14 février 2025

Renseignements : Prof. Pengjuan Zu, tél. 044/6322376, email

Si vous souhaitez relever ce défi, veuillez postuler en ligne sur notre site en joignant votre dossier complet (lettre de motivation, CV, diplômes et certificats de travail). 
Nous précisons que seules les offres de candidatures déposées en ligne sur notre plateforme de recrutement seront prises en considération.

L’Université de Neuchâtel accorde une importance particulière à l’égalité et à la diversité : www.unine.ch/egalite. 

Postdoctoral researcher Position in Natural Products Metabolomics and Computational Mass Spectrometry

The Bioactive Natural Products Unit of University of Geneva's School of Pharmaceutical Sciences is seeking a talented postdoctoral researcher to join an ANR-SNF funded project MetaboLinkAI. This innovative initiative aims to transform natural product (NP) research and metabolomics through a multidisciplinary approach combining knowledge graphs (KG), artificial intelligence (AI), and machine learning techniques. By integrating advanced analytical methods such as mass spectrometry (MS) and nuclear magnetic resonance (NMR) with cutting-edge computational tools, the NP research part of MetaboLinkAI aims to accelerate the futur discovery of bioactive NPs and study the untapped potential of nature's chemical diversity.

As part of the MetaboLinkAI consortium, the postdoctoral researcher will focus on developing methods for comprehensively characterising the metabolome of chemodiverse plant and micro-organisms. These approaches will build on the project's constantly evolving AI tools and will serve as a proof of concept, in particular for the efficient identification of original bioactive natural products.

 

Position details

• Role: Postdoctoral Researcher (100%)
• Lab: Phytochemistry and Bioactive Natural Products research unit, School of Pharmaceutical Sciences, University of Geneva, Switzerland

 

Key responsibilities

• Processing and integrating data issued from LC-MS metabolite profiling of natural extracts into a Metabolomics Knowledge Graph (MS/KG)
• Collaborating on targeted isolation of NPs for proof-of-concept studies in bioactive scaffold discovery
• Assisting in generating fully characterized extracts for benchmarking purposes
• Collaborating with AI experts to deploy next-generation AI solutions in metabolomics

 

Required Skills

• PhD/ experience in natural product chemistry, metabolomics, cheminformatics, bioinformatics, computational chemistry, or a related field
• Familiarity with metabolomics data analysis and interpretation
• Proficiency in programming languages commonly used in metabolomics (e.g., R, Python)
• Rigorous and well organised for methodological data management

 

Laboratory Expertise

The Phytochemistry and Bioactive Natural Products research unit, led by Jean-Luc Wolfender, has experience in profiling and isolating metabolites from complex extracts. While a background in these wet-lab techniques is beneficial, the laboratory is prepared to provide training in these areas to candidates with strong computational skills. This position offers the opportunity to work on cutting-edge research that aims to transform metabolomics and NP discovery while learning from experts in the field of NP chemistry and metabolomics.

 

Application and contact

Please send your online application file including CV, motivation letter and addresses of two referees via email to Prof. Jean-Luc Wolfender

 

Starting date

01.04.2025 or date to be agreed. The duration of the commitment is limited to 12 months, renewable up to a period of 3 years.

Postdoc Position in Proteomics and Biomarker Discovery (80%)

Laboratory of Clinical Chemistry, Zürich University of Applied Sciences

The Laboratory of Clinical Chemistry at the Zürich University of Applied Sciences is seeking a highly motivated Postdoctoral Researcher in the field of Mass Spectrometry, Proteomics, and Biomarker Discovery. This position is available immediately.

Your Role
This position offers a unique opportunity to conduct innovative research in proteomics and biomarker discovery, with a focus on integrating advanced mass spectrometry technologies with biochemical workflows to discover new biomarkers and potential drug targets. Your primary responsibilities:

• Leveraging experience with advanced LC-MS/MS systems (e.g., Q-TOF, Orbitrap, etc) and adapting methodologies to the research objectives.
• Designing workflows and conducting discovery and targeted proteomics experiments using techniques such as data-dependent acquisition (DDA), data-independent acquisition (DIA), label-free quantification (LFQ), or isotopic labeling to achieve comprehensive proteome coverage and precise quantitation of biomolecules.
• Analyzing complex proteomics datasets using state-of-the-art data analysis tools and interpreting results in a biological context
• Establishing and Implementing biochemical workflows, including protein purification, pull-down assays, and immunoprecipitation (IP), for studying protein interactions and functional characterization. 
• Development of chemoproteomics workflows by using activity-based probes for targeting and profiling active proteins and integrating this data with conventional proteomics approaches for biomarker discovery and functional studies.
• Handling diverse human biological samples, including plasma, serum, and tissues.
• Supporting the development of cellular models for functional studies.
• Working independently while actively collaborating with group members on shared projects, publish manuscripts in peer-reviewed journals, assist in application for third-party funding and present findings at lab meetings and international conferences.
• Supervise junior staff, and support teaching activities of students within the institute.

 

Your Profile

• A Ph.D. in Biochemistry, Chemical Biology, or a related field.
• A strong publication record demonstrating expertise in advanced mass spectrometry technologies and proteomics workflows.
• Hands-on experience with high-resolution LC-MS/MS systems (e.g., Q-TOF or Orbitrap) and their applications in complex biological systems and familiarity with sample preparation techniques for proteomics, including protein extraction, digestion, and fractionation.
• Expertise in proteomics data analysis using state of the art software.
• Competence in protein biochemistry, performing biochemical assays and workflows and working with human clinical samples (Serum, Plasma, tissues, etc)
• Additional experience in working with chemoproteomics workflows or expertise in combining limited proteolysis with mass spectrometry will be given a special consideration.
• Experience in cell biology or cell culturing techniques (2D and 3D) techniques is considered a plus.

 

Apply online on the company job site

Assistant engineer position in N-terminomics at I2BC University Paris-Saclay (20km south of Paris): 10 months

Working context: The Institute for Integrative Biology of the Cell (I2BC) is a large mixed research unit created on January 1, 2015. It is jointly supervised by the CNRS, CEA, and Université Paris-Saclay, with additional partnerships including INRAe, INSERM, and Université Paris Diderot, among others. Located 20 km from Paris, France, the institute fosters interdisciplinary research at the cutting edge of biological sciences (https://www.i2bc.paris-saclay.fr).

Host laboratory: Our research group (Protein Maturation, Cell fate and Therapeutics, https://www.i2bc.paris-saclay.fr/equipe-protein-maturation-cell-fate-therapeutics/), headed by C. Giglione, is seeking a highly motivated and skilled assistant engineer to join our team. Our group focuses on a range of modifications that affect proteins. These modifications share the common feature of targeting reactive amino groups, either at the N-terminus or on the side chains of lysines. The team aims to understand the nature and biological effects of these modifications as well as the impact of these modifications on the maintenance of a functional proteome. In this context, our research focus includes identifying the protein populations involved, exploring competition between different modifications on the same chemical group, and examining the physiological adjustment of their stoichiometry, which lies at the heart of proteostasis. Protein analysis and modification studies are conducted using mass spectrometry, leveraging instruments managed by the platform adjacent to the team’s location. The properties of the enzymes catalyzing these modifications are characterized both in vitro through biochemical approaches and in vivo through genetic methods (e.g., loss-of-function studies). The nature of the modifications can also be analyzed in cell extracts from various species using targeted approaches for specific amino groups or broader methods. In all cases, a quantitative analysis is prioritized and carefully examined. Computational tools and databases are developed to support these analyses. Additionally, biophysical in vitro studies or in-cellulo cellular biology approaches are employed to enhance the understanding of the distribution of modified proteins across different compartments.

Candidate’s profile: We are looking for an assistant engineer with experience in protein biochemistry (fractionation using high or medium-pressure chromatography) and mass spectrometry techniques. Experience in approaches for N-terminal proteomic characterization and quantification in complex extracts as well as protein modification enrichment and analysis will be highly appreciated. Over time, the candidate will be expected to independently conduct routine MS experiments and analyze the resulting data.

This opportunity is ideal for someone who is driven, curious, and passionate about proteomics and 
protein biochemistry.

Salary: ~40 k€ for 10 months (extension possible depending on funding)

How to Apply:
If this opportunity aligns with your skills and career aspirations, please send your CV with at least two references and a cover letter outlining your relevant experience and motivation to Carmela Giglione at CNRS (Email) and Carmela Giglione at I2BC (Email). 

R&D Software Developer

Our scientists and engineers design, manufacture, and optimize high performance mass spectrometers for new applications to support researchers and industrial customers around the world.  We are headquartered in Thun, Switzerland, with regional offices in China, Japan, Korea and the United States. Our diverse team members cultivate a collaborative and creative work environment. Together we deliver the highest quality products and service to ensure our customers’ success.

Location: Thun, Switzerland

 

Description

TOFWERK is seeking a software engineer to strengthen our team developing software for our time-of-flight mass spectrometers. The successful applicant will combine programming and scientific experience with their communication skills to meet the tailored requirements for a diverse set of stakeholders and customers. They will work in tandem with R&D teams, other software team members, and members of the product teams to integrate the user interface applications with the underlying TOFWERK libraries and services driving the instrument control functionality. They will directly liaise with the R&D and instrument teams in rapid development of software during prototyping and feedback cycles, and to ensure that the stakeholders requirements are comprehensively documented. Based on their knowledge of the field and use of TOFWERK technology, they will provide suggestions and feedback regarding potential short- and long-term product improvements and developments.

 

Required Skills

• 3+ years experience in software development using C#
• Master’s level education in the sciences
• Relevant certification or proven track record in front-end software engineering
• Interest in collaborating with non-software R&D staff and product teams
• Independent, well-structured, and goal-oriented working style
• Fluency in English

 

Desired Skills 

• Experience using Agile development principles, particularly Kanban
• Experience working as part of an international team across multiple time zones
• Basic proficiency in German
• Knowledge of Python and/or C++

 

What We Offer 

• Exciting projects in state-of-the-art mass spectrometry
• Working with a creative international team
• An open culture that encourages new ideas
• Flexible working hours
• A bright, spacious workplace in beautiful Thun, Switzerland
• Attractive pension scheme

 

We look forward to receiving your application by email, Reference HR-693